Peripapillary nerve fiber layer thickness changes after macular photocoagulation for clinically significant diabetic macular edema

To evaluate the effect of macular photocoagulation [MPC] on peripapillary nerve fiber layer [PNFL] thickness measurement in patients with clinically significant diabetic macular edema [CSME]. This study was a prospective interventional case series. Patients with CSME underwent MPC. Optical coherence tomography [OCT] was used to measure the PNFL and central macular thicknesses before and 3 months after MPC. Thirty-three eyes of 25 patients with a mean age of 59.4 +/- 7.2 years were included. There was no statistically significant difference between pre- and post-MPC mean best corrected visual acuity [0.35 +/- 0.29 and 0.40 +/- 0.23 LogMAR, respectively, P = 0.2]. Mean baseline and 3 months central macular subfield thickness was 305.9 +/- 90.7 and 317.5 +/- 112.4 microns, respectively [P = 0.1]. Peripapillary nerve fiber layer thickness was 105.7 +/- 10.0 before and 106.1 +/- 9.9 three months after MPC [P = 0.7]. No significant differences were found between pre and post MPC measurements in temporal, nasal, inferior and superior nerve fiber layer thickness in each quadrant around optic nerve head [P > 0.05]. Macular photocoagulation has no statistically significant effect on PNFL thickness measurements in patients with CSME

Effect of yellow-tinted intraocular lens on standard automated perimetry and short wavelength automated perimetry in patients with glaucoma

To investigate the effect of cataract surgery and yellow-tinted intraocular lens [IOLs] implantation on perimetry indices of short-wavelength automated perimetry [SWAP] and standard automated perimetry [SAP] testing in patients with coexisting cataract and glaucoma. In this prospective comparative case series, phacoemulsification with implantation of yellow-tinted Acrysof Natural IOL was performed in 16 eyes of 16 patients with visually significant cataract [best-corrected visual acuity [VA] better than 20/120] and mild to moderate glaucoma. Pre- and postoperative values for VA and for perimetry indices including mean deviation [MD], pattern standard deviation [PSD], and foveal threshold [FT] from both SAP and SWAP testing were compared. Postoperative VA improved significantly after cataract surgery and yellow-tinted IOL implantation [P < 0.001]. After cataract extraction and IOL implantation, MD and FT on SWAP testing improved significantly [P = 0.001]; however, there was no statistically significant change with SAP testing between the pre- and postoperative perimetry indices. There was no statistically significant change in PSD with either SAP or SWAP testing postoperatively. The differences between pre- and postoperative values for all perimetry indices under study were not significant when comparing SAP with SWAP tests, except for MD which had improved statistically significantly in SWAP testing [P = 0.03]. In mild to moderate glaucoma patients with cataracts, the perimetry indices of SWAP testing improved after phacoemulsification and yellow-tinted IOL implantation. This suggests that the yellow-tinted IOLs have less effect on SWAP testing than visually significant cataracts